Searchable abstracts of presentations at key conferences in endocrinology

ea0089o9 | Other | NANETS2022

Leveraging Transcriptomics to Grade Pancreatic Neuroendocrine Neoplasms(NENs) and Assess Molecular Alterations Associated with Somatostatin Receptor(SSTR) Subtype Expression

Lou Emil , Gandhi Nishant , Farrell Alex , Xiu Joanne , Seeber Andreas , Shaalan Beg Muhammad , Darabi Sourat , J. Demeure Michael , Abraham Jim , Oberley Matthew , Marshall John , Soares Heloisa

Background: SSTR substypes are collectively expressed in the majority of NENs. However, SSTR subtype expression is not routinely assessed for clinical decision-making, including patients eligible for targeted radionucleotide therapy. Elucidating the landscape of SSTR subtypes in context of molecular profiles for low-grade (LG-) and high-grade NENs (HG-NENs) provides an opportunity to better tailor targeted therapy. Here, we leverage the ability of transcriptomics to predict NE...